Endocrine Abstracts

Pheochromocytomas, tumors derived from adrenal medulla, are characterized by a polymorphic clinical picture dominated by paroxysmal hypertension. Between the clinical, laboratory and pathology data, discordances are frequently seen.Patients and Methods: Thirty five cases of pheochromocytoma and paraganglioma (10 men) with adrenal tumors and hypertension were confirmed with pheochromocytoma. They were aged 53.68±12.75 years (36–75), while the tu...

Neurofibromatosis type 1 is an autosomal dominant genetic disorder that results from loss of function of the neurofibromin gene, leading to failure of a tumor suppressor mechanism. Usually characterized by ‘café-au-lait’ spots, cutaneous neurofibromas, and a predisposition for tumorigenesis occurring in childhood, NF1 can have variable clinical expression, with ‘mildly symptomatic’ cases eluding diagnosis until adulthood.A 53-yea...

A 29-year-old female diagnosed 1.5 years ago with Graves’ disease, presented with severe thyrotoxicosis and a large, diffuse goiter after an attempt to taper the anti-thyroid medication. She had also noticed 4 days before presentation right arm mild paresis. The neurological exam confirmed the sensitive and motor deficit. Blood assays confirmed severe thyrotoxicosis (TSH <0.03 mUI/l, fT4=25.6 pmol/l, T3 >500 ng/dl), high levels of anti-thyroi...

Purpose: GH deficiency (GHD) is associated with increased cardiovascular events, however, the detailed mechanisms have not been assessed yet extensively. We set up this study in order to evaluate cardiac, arterial, and endothelial function, by conventional echo, TDI, and biomarkers (proBNP and troponin I), in GHD patients by comparison with normal individuals with similar cardiovascular risk factors profile.Methods: Thirty GHD patients (46±14 years,...